Forty Signs of Rain (3 page)

Anna wrinkled her nose at this, surprising Frank; although she was proper, she was not prudish. Then he got it: her disapproval was not at the joke, but at the idea that these new arrivals would be that hapless. She said, “I think they’re more together than that. I think they’ll be interesting to have here.”

Homo sapiens
is a species that exhibits sexual dimorphism. And it’s more than a matter of bodies; the archaeological record seemed to Frank to support the notion that the social roles of the two sexes had deviated early on. These differing roles could have led to differing thought processes, such that it would be possible to characterize plausibly the existence of unlike approaches even to ostensibly non-gender-differentiated activities, such as science. So that there could be a male practice of science and a female practice of science, in other words, and these could be substantially different activities.

These thoughts flitted through Frank’s mind as their elevator ride ended and he and Anna walked down the hall around to their offices. Anna was as tall as he was, with a nice figure, but the dimorphism differentiating them extended to their habits of mind and their scientific practice, and that might explain why he was a bit uncomfortable with her. Not that this was a full characterization of his attitude. But she did science in a way that he found annoying. It was not a matter of her being warm and fuzzy, as you might expect from the usual characterizations of feminine thought—on the contrary, Anna’s scientific work (she still often
coauthored papers in statistics, despite her bureaucratic load) often displayed a finicky perfectionism that made her a very meticulous scientist, a first-rate statistician—smart, quick, competent in a range of fields and really excellent in more than one. As good a scientist as one could find for the rather odd job of running the Bioinformatics Division at NSF, good almost to the point of exaggeration—too precise, too interrogatory—it kept her from pursuing a course of action with drive. Then again, at NSF maybe that was an advantage.

In any case she was so intense about it. A kind of Puritan of science, rational to an extreme. And yet of course at the same time that was all such a front, as with the early Puritans; the hyperrational coexisted in her with all the emotional openness, intensity, and variability that was the American female interactional paradigm and social role. Every female scientist was therefore potentially a kind of Mr. Spock, the rational side foregrounded and emphasized while the emotional side was denied, and the two coexisting at odds with one another.

On the other hand, judged on that basis, Frank had to admit that Anna seemed less split-natured than many women scientists he had known. Pretty well integrated, really. He had spent many hours of the past year working with her, engaged in interesting discussions in the pursuit of their shared work. No, he liked her. The discomfort came not from any of her irritating habits, not even the nit-picking or hairsplitting that made her so strikingly eponymous (though no one dared joke about that to her), habits that she couldn’t seem to help and didn’t seem to notice—no—it was more the way her hyperscientific attitude combined with her passionate female expressiveness to suggest a complete science, or even a complete humanity. It reminded Frank of himself.

Not of the social self that he allowed others to see, admittedly; but of his internal life as he alone experienced it. He too was stuffed with extreme aspects of both rationality and emotionality. This was what made him uncomfortable: Anna was too much like him. She reminded him of things about himself he did not want to think about. But he was helpless to stop his trains of thought. That was one of his problems.

Halfway around the circumference of the sixth floor, they came to
their offices. Frank’s was one of a number of cubicles carving up a larger space; Anna’s was a true office right across from his cubicle, a room of her own, with a foyer for her secretary Aleesha. Both their spaces, and all the others in the maze of crannies and rooms, were filled with the computers, tables, file cabinets, and crammed bookshelves that one found in scientific offices everywhere. The decor was standard degree-zero beige for everything, indicating the purity of science.

In this case it was all rendered human, and even handsome, by the omnipresent big windows on the interior sides of the rooms, allowing everyone to look across the central atrium and into all the other offices. This combination of open space and the sight of fifty to a hundred other humans made each office a slice or echo of the savannah. The occupants were correspondingly more comfortable at the primate level. Frank did not suffer the illusion that anyone had consciously planned this effect, but he admired the instinctive grasp on the architect’s part of what would get the best work out of the building’s occupants.

He sat down at his desk. He had angled his computer screen away from the window so that when necessary he could focus on it, but now he sat in his chair and gazed out across the atrium. He was near the end of his yearlong stay at NSF, and the workload, while never receding, was simply becoming less and less important to him. Piles of articles and hard-copy jackets lay in stacks on every horizontal surface, arranged in Frank’s complex throughput system. He had a lot of work to do. Instead he looked out the window.

The colorful mobile filling the upper half of the atrium was a painfully simple thing, basic shapes in primary colors, very like a kindergartner’s scribble. Frank’s many activities included rock climbing, and often he had occupied his mind by imagining the moves he would need to make to climb the mobile. There were some hard sections, but it would make for a fun route.

Past the mobile, he could see into one hundred and eight other rooms (he had counted). In them people typed at screens, talked in couples or on the phone, read, or sat in seminar rooms around paper-strewn tables, looking at slide shows, or talking. Mostly talking. If the interior of
the National Science Foundation were all you had to go on, you would have to conclude that doing science consisted mostly of sitting around in rooms talking.

This was not even close to true, and it was one of the reasons Frank was bored. The real action of science took place in laboratories, and anywhere else experiments were being conducted. What happened here was different, a kind of metascience, one might say, which coordinated scientific activities, or connected them to other human action, or funded them. Something like that; he was having trouble characterizing it, actually.

The smell of Anna’s Starbucks latte wafted in from her office next door, and he could hear her on the phone already. She too did a lot of talking on the phone. “I don’t know, I have no idea what the other sample sizes are like.… No, not statistically insignificant, that would mean the numbers were smaller than the margin of error. What you’re talking about is just statistically meaningless. Sure, ask him, good idea.”

Meanwhile Aleesha, her assistant, was on her phone as well, patiently explaining something in her rich D.C. contralto. Unraveling some misunderstanding. It was an obvious if seldom acknowledged fact that much of NSF’s daily business was accomplished by a cadre of African-American women from the local area, women who often seemed decidedly unconvinced of the earth-shattering importance that their mostly Caucasian employers attributed to the work. Aleesha, for instance, displayed the most skeptical politeness Frank had ever seen; he often tried to emulate it, but without, he feared, much success.

Anna appeared in the doorway, tapping on the doorjamb as she always did, to pretend that his space was an office. “Frank, I forwarded a jacket to you, one about an algorithm.”

“Let’s see if it arrived.” He hit
CHECK MAIL
, and up came a new one from
[email protected]
. He loved that address. “It’s here, I’ll take a look at it.”

“Thanks.” She turned, then stopped. “Hey listen, when are you due to go back to UCSD?”

“End of July or end of August.”

“Well, I’ll be sorry to see you go. I know it’s nice out there, but we’d love it if you’d consider putting in a second year, or even think about staying permanently, if you like it. Of course you must have a lot of irons in the fire.”

“Yes,” Frank said noncommittally. Staying longer than his one-year stint was completely out of the question. “That’s nice of you to ask. I’ve enjoyed it, but I should probably get back home. I’ll think about it, though.”

“Thanks. It would be good to have you here.”

Much of the work at NSF was done by visiting scientists, who came on leave from their home institutions to run NSF programs in their area of expertise for periods of a year or two. The grant proposals came pouring in by the thousands, and program directors like Frank read them, sorted them, convened panels of outside experts, and ran the meetings in which these experts rated batches of proposals in particular fields. This was a major manifestation of the peer-review process, a process Frank thoroughly approved of—in principle. But a year of it was enough.

Anna had been watching him, and now she said, “I suppose it is a bit of a rat race.”

“Well, no more than anywhere else. In fact if I were home it’d probably be worse.”

They laughed.

“And you have your journal work too.”

“That’s right.” Frank waved at the piles of typescripts: three stacks for
Review of Bioinformatics
, two for
The Journal of Sociobiology
. “Always behind. Luckily the other editors are better at keeping up.”

Anna nodded. Editing a journal was a privilege and an honor, even though usually unpaid—indeed, one often had to continue to subscribe to a journal just to get copies of what one had edited. It was another of science’s many noncompensated activities, part of its extensive economy of social credit.

“Okay,” Anna said. “I just wanted to see if we could tempt you. That’s how we do it, you know. When visitors come through who are particularly good, we try to hold on to them.”

“Yes, of course.” Frank nodded uncomfortably. Touched despite himself; he valued her opinion. He rolled his chair toward his screen as if to get to work, and she turned and left.

He clicked to the jacket Anna had forwarded. Immediately he recognized one of the investigators’ names.

“Hey Anna?” he called out.

“Yes?” She reappeared in the doorway.

“I know one of the guys on this jacket. The P.I. is a guy from Caltech, but the real work is by one of his students.”

“Yes?” This was a typical situation, a younger scientist using the prestige of his or her advisor to advance a project.

“Well, I know the student. I was the outside member on his dissertation committee, a few years ago.”

“That wouldn’t be enough to be a conflict.”

Frank nodded as he read on. “But he’s also been working on a temporary contract at Torrey Pines Generique, which is a company in San Diego that I helped start.”

“Ah. Do you still have any financial stake in it?”

“No. Well, my stocks are in a blind trust for the year I’m here, so I can’t be positive, but I don’t think so.”

“But you’re not on the board, or a consultant?”

“No no. And it looks like his contract there was due to be over about now anyway.”

“That’s fine, then. Go for it.”

No part of the scientific community could afford to be
too
picky about conflicts of interest. If they were, they’d never find anyone free to peer-review anything; hyperspecialization made every field so small that within them, everyone seemed to know everyone. Because of that, so long as there were no current financial or institutional ties with a person, it was considered okay to proceed to evaluate their work in the various peer-review systems.

But Frank had wanted to make sure. Yann Pierzinski had been a very sharp young biomathematician—he was one of those doctoral students whom one watched with the near certainty that one would hear from
them again later in their career. Now here he was, with something Frank was particularly interested in.

“Okay,” he said now to Anna. “I’ll put it in the hopper.” He closed the file and turned as if to check out something else.

After Anna was gone, he pulled the jacket back up. “Mathematical and Algorithmic Analysis of Palindromic Codons as Predictors of a Gene’s Protein Expression.” A proposal to fund continuing work on an algorithm for predicting which proteins any given gene would express.

Very interesting. This was an assault on one of the fundamental mysteries, an unknown step in biology that presented a considerable blockage to any robust biotechnology. The three billion base pairs of the human genome encoded along their way some hundred thousand genes; and most of these genes contained instructions for the assembly of one or more proteins, the basic building blocks of organic chemistry and life itself. But which genes expressed which proteins, and how exactly they did it, and why certain genes would create more than one protein, or different proteins in different circumstances—all these matters were very poorly understood, or completely mysterious. This ignorance made much of biotechnology an endless and very expensive matter of trial and error. A key to any part of the mystery could be very valuable.

Frank scrolled down the pages of the application with practiced speed. Yann Pierzinski, Ph.D. in biomath, Caltech. Still doing postdoc work with his thesis advisor there, a man Frank had come to consider a bit of a credit hog, if not worse. It was interesting, then, that Pierzinski had gone down to Torrey Pines to work on a temporary contract, for a bioinformatics researcher whom Frank didn’t know. Perhaps that had been a bid to escape the advisor. But now he was back.

Frank dug into the substantive part of the proposal. The algorithm set was one Pierzinski had been working on even back in his dissertation. Chemical mechanics of protein creation as a sort of natural algorithm, in effect. Frank considered the idea, operation by operation. This was his real expertise; this was what had interested him from childhood, when the puzzles solved had been simple ciphers. He had always loved this work, and now perhaps more than ever, offering as it did a complete escape
from consciousness of himself. Why he might want to make that escape remained moot; howsoever it might be, when he came back he felt refreshed, as if finally he had been in a good place.