Secondary Schizophrenia (122 page)

multiply affected with bipolar

bipolar disorder.

density of schizophrenia. Mol

disorder provides further support

Neuropsychopharmacology, 1993.

Psychiatry, 2005.
10
:1097–103.

for the presence of a susceptibility

9
:31–40.

208. Zhang F., Sarginson J., Crombie

locus on chromosome 12q23-q24,

200. Hwu H. G., Liu C. M., Fann C. S.,

C.,
et al.
Genetic association

and suggests the presence of

et al.
Linkage of schizophrenia

between schizophrenia and the

additional loci on 1p and 1q.

with chromosome 1q loci in

DISC1 gene in the Scottish

Psychiatr Genet, 2003.
13
:77–
Taiwanese families. Mol

population. Am J Med Genet B

84.

Psychiatry, 2003.
8
:445–52.

Neuropsychiatr Genet, 2006.

216. Detera-Wadleigh S. D., Badner J.

141
:155–9.

201. Ekelund J., Hennah W.,

A.,
et al.
A high-density genome

Hiekkalinna T.,
et al.
Replication
209. Liu Y. L., Fann C. S., Liu C. M.,

scan detects evidence for a

of 1q42 linkage in Finnish

et al.
A single nucleotide

bipolar-disorder susceptibility

schizophrenia pedigrees. Mol

polymorphism fine mapping

locus on 13q32 and other

Psychiatry, 2004.
9
:1037–41.

study of chromosome 1q42.1

potential loci on 1q32 and

18p11.2. Proc Natl Acad Sci USA,

202. Hennah W., Tomppo L.,

reveals the vulnerability genes for

1999.
96
:5604–9.

Hiekkalinna T.,
et al.
Families

schizophrenia, GNPAT and

with the risk allele of DISC1 reveal

DISC1: Association with

217. Kockelkorn T. T., Arai M.,

a link between schizophrenia and

impairment of sustained

Matsumoto H.,
et al.
Association

another component of the same

attention. Biol Psychiatry, 2006.

study of polymorphisms in the 5’

molecular pathway, NDE1. Hum

60
:554–62.

upstream region of human DISC1

Mol Genet, 2007.
16
:453–62.

210. Hodgkinson C. A., Goldman D.,

gene with schizophrenia. Neurosci

Lett, 2004.
368
:41–5.

203. Hamshere M. L., Bennett P.,

Jaeger J.,
et al.
Disrupted in

Williams N.,
et al.
Genomewide

schizophrenia 1 (DISC1):

218. Burdick K. E., Hodgkinson C. A.,

linkage scan in schizoaffective

association with schizophrenia,

Szeszko P. R.,
et al.
DISC1 and

disorder: significant evidence for

schizoaffective disorder, and

neurocognitive function in

linkage at 1q42 close to DISC1,

bipolar disorder. Am J Hum

schizophrenia. Neuroreport, 2005.

and suggestive evidence at 22q11

Genet, 2004.
75
:862–72.

16
:1399–402.

and 19p13. Arch Gen Psychiatry,

211. Callicott J. H., Straub R. E.,

219. Ishizuka K., Paek M., Kamiya A.,

2005.
62
:1081–8.

Pezawas L.,
et al.
Variation in

et al.
A review of Disrupted-

204. Hennah W., Varilo T., Kestila M.,

DISC1 affects hippocampal

In-Schizophrenia-1 (DISC1):

et al.
Haplotype transmission

structure and function and

neurodevelopment, cognition,

analysis provides evidence of

increases risk for schizophrenia.

and mental conditions. Biol

association for DISC1 to

Proc Natl Acad Sci USA, 2005.

Psychiatry, 2006.
59
:1189–97.

schizophrenia and suggests

102
:8627–32.

220. Austin C. P., Ky B., Ma L.,
et al.

sex-dependent effects. Hum Mol

212. Hashimoto R., Numakawa T.,

Expression of Disrupted-In-

Genet, 2003.
12
:3151–9.

Ohnishi T.,
et al.
Impact of the

Schizophrenia-1, a

205. Thomson P. A., Wray N. R., Millar

DISC1 Ser704Cys polymorphism

schizophrenia-associated gene, is

J. K.,
et al.
Association between

on risk for major depression,

prominent in the mouse

the TRAX/DISC locus and both

brain morphology and ERK

hippocampus throughout brain

bipolar disorder and

signaling. Hum Mol Genet, 2006.

development. NeuroScience, 2004.

schizophrenia in the Scottish

15
:3024–3033.

124
:3–10.

population. Mol Psychiatry, 2005.

213. DeRosse P., Hodgkinson C. A.,

221. Austin C. P., Ma L., Ky B.,
et al.

306

10
:657–668, 616.

Lencz T.,
et al.
Disrupted in

DISC1 (Disrupted in

Chapter 23 – The status of genetic investigations of schizophrenia

Schizophrenia-1) is expressed in

schizophrenia and other major

populations: new roles for old

limbic regions of the primate

neurological disorders. Mol Cell

friends? Hum Hered. 2000.

brain. Neuroreport, 2003.

Neurosci, 2004.
25
:42–55.

50
:57–65.

14
:951–4.

229. Mackie S., Millar J. K., Porteous

239. Service S., DeYoung J.,

222. Porteous D. J., Thomson P.,

D. J. Role of DISC1 in neural

Karayiorgou M.,
et al.
Magnitude

Brandon N. J.,
et al.
The genetics
development and schizophrenia.

and distribution of linkage

and biology of DISC1 – an

Curr Opin Neurobiol, 2007.

disequilibrium in population

emerging role in psychosis and

17
:95–102.

isolates and implications for

cognition. Biol Psychiatry, 2006.

230. Morris D. W., Rodgers A.,

genomewide association studies.

60
:123–31.

McGhee K. A.,
et al.
Confirming

Nat Genet, 2006.
38
:556–60.

223. Schurov I. L., Handford E. J.,

RGS4 as a susceptibility gene for

240. Varilo T., Peltonen L. Isolates and

Brandon N. J.,
et al.
Expression of
schizophrenia. Am J Med Genet B

their potential use in complex

disrupted in schizophrenia 1

Neuropsychiatr Genet, 2004.

gene mapping efforts. Curr Opin

(DISC1) protein in the adult

125
:50–3.

Genet Dev, 2004.
14
:316–23.

and developing mouse brain

231. Kirkpatrick B., Xu L., Cascella N.,

241. Botstein D., Risch N. Discovering

indicates its role in

et al.
DISC1 immunoreactivity at

genotypes underlying human

neurodevelopment. Mol

the light and ultrastructural level

phenotypes: past successes for

Psychiatry, 2004.
9
:
in the human neocortex. J Comp

mendelian disease, future

1100–10.

Neurol, 2006.
497
:436–50.

approaches for complex disease.

224. Sawamura N., Sawamura-

232. Millar J. K., James R., Brandon N.

Nat Genet, 2003.
33
(Suppl):
Yamamoto T., Ozeki Y.,
et al.
A

J.,
et al.
DISC1 and DISC2:

228–37.

form of DISC1 enriched in

discovering and dissecting

242. Kaessmann H., Zollner S.,

nucleus: altered subcellular

molecular mechanisms

Gustafsson A. C.,
et al.
Extensive
distribution in orbitofrontal

underlying psychiatric illness.

linkage disequilibrium in small

cortex in psychosis and

Ann Med, 2004.
36
:367–78.

human populations in Eurasia.

substance/alcohol abuse. Proc Natl

Am J Hum Genet, 2002.

Acad Sci USA, 2005.
102
:1187–
233. Camargo L. M., Collura V., Rain J.

70
:673–85.

92.

C.,
et al.
Disrupted in

Schizophrenia 1 Interactome:

243. Topol E. J., Frazer K. A. The

225. Ozeki Y., Tomoda T., Kleiderlein

evidence for the close connectivity

resequencing imperative. Nat

J.,
et al.
Disrupted-in-

of risk genes and a potential

Genet, 2007.
39
:439–40.

Schizophrenia-1 (DISC-1):

synaptic basis for schizophrenia.

mutant truncation prevents

244. Vavouri T., Walter K., Gilks W. R.,

Mol Psychiatry, 2007.
12
:74–
binding to NudE-like (NUDEL)

et al.
Parallel evolution of

86.

and inhibits neurite outgrowth.

conserved non-coding elements

Proc Natl Acad Sci USA, 2003.

234. Millar J. K., Pickard B. S., Mackie

that target a common set of

100
:289–94.

S.,
et al.
DISC1 and PDE4B are

developmental regulatory genes

interacting genetic factors in

from worms to humans. Genome

226. Miyoshi K., Honda A., Baba K.,

schizophrenia that regulate cAMP

Biol, 2007.
8
:R15.

et al.
Disrupted-In-Schizophrenia

signaling. Science, 2005.
310
:
1, a candidate gene for

245. Mirnics K., Levitt P., Lewis D. A.

1187–91.

schizophrenia, participates in

Critical appraisal of DNA

neurite outgrowth. Mol

235. Todd J. A. Statistical false positive
microarrays in psychiatric

Psychiatry, 2003.
8
:685–94.

or true disease pathway? Nat

genomics. Biol Psychiatry, 2006.

Genet, 2006.
38
:731–3.

60
:163–76.

227. James R., Adams R. R., Christie S.,

et al.
Disrupted in Schizophrenia

236. Kendler K. S. Reflections on the

246. Callinan P. A., Feinberg A. P. The

1 (DISC1) is a multicompart-

relationship between psychiatric

emerging science of epigenomics.

mentalized protein that predomi-

genetics and psychiatric nosology.

Hum Mol Genet, 2006. 15 Spec

nantly localizes to mitochondria.

Am J Psychiatry, 2006.
163
:
No
1
:R95–101.

Mol Cell Neurosci, 2004.

1138–46.

247. Feinberg A. P. Phenotypic

26
:112–22.

237. Shastry B. S. Pharmacogenetics

plasticity and the epigenetics of

228. Brandon N. J., Handford E. J.,

and the concept of individualized

human disease. Nature, 2007.

Schurov I.,
et al.
Disrupted in

medicine. Pharmacogenomics J,

447
:433–40.

Schizophrenia 1 and Nudel form a

2006.
6
:16–21.

248. Pillai R. S. MicroRNA function:

neurodevelopmentally regulated

238. Jorde L. B., Watkins W. S., Kere J.,
multiple mechanisms for a tiny

protein complex: implications for

et al.
Gene mapping in isolated

RNA? RNA, 2005.
11
:1753–61.

307

Organic Syndromes of Schizophrenia – Section 3

249. Roeder K., Bacanu S. A.,

Am J Hum Genet, 2006.

block structure but conservation

Wasserman L.,
et al.
Using linkage
78
:243–52.

in tag SNP patterns among global

genome scans to improve power